Hepazec

Hepazec Film-coated Tablet 550 Mg is a very important medicine designed to relieve specific gastrointestinal and hepatic problems. In this guide, we go into finer detail on the active ingredient, including its uses, possible side effects and alternatives. Stay informed about your health and interruptions in education.

Rifaximin is a semi-synthetic, non-systemic antibiotic based on rifamycin, which means that the drug does not pass through the intestinal wall and does not enter the bloodstream, as is common with other types of antibiotics. It is used for the treatment of traveler’s diarrhea caused by E. coli, to reduce the risk of recurrence of overt hepatic encephalopathy, and for the treatment of diarrhea-dominant irritable bowel syndrome in adult women and men.

Pharmacodynamics:

Rifaximin inhibits RNA synthesis in susceptible bacteria by binding to the beta subunit of the bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This binding blocks the translocation, causing the transcription to stop. As a result, the bacteria can no longer produce proteins, preventing them from reproducing.

Pharmacokinetics:

Rifaximin is not systemically absorbed, so there are no data on pharmacokinetics. The half-life is about 6 hours.

Side Effects:

Rifaximin has few unwanted other effects. These side effects are generally mild and rare. This is mainly because very little of the drug is absorbed from the intestine, so there are no systemic side effects.

Toxicological Data:

LD50 (rat, oral): > 2000 mg-kg-1

Chemical and Physical Properties: