Casodex
Casodex (bicalutamide) is a non-steroidal anti-androgen for treating Stage D2 metastatic prostate cancer in combination with LHRH hormone therapy. This androgen receptor inhibitor blocks testosterone effects on cancer cells. Requires oncologist or urologist specialist supervision with regular monitoring for liver function and treatment effectiveness throughout therapy.
- Prescription Required
| Brand | Form | Price | Qty | Action |
|---|---|---|---|---|
| Casodex Brand | 150mg 28 Tablets | $219.00 | ||
| Casodex Brand | 50mg 28 Tablets | $91.00 |
- Please note all prices are in US dollars
Buy Casodex Online – Anti-Androgen Therapy for Prostate Cancer
Casodex (bicalutamide) is a non-steroidal anti-androgen medication used to treat advanced prostate cancer. This prescription medicine works by blocking the effects of male hormones (androgens) that help prostate cancer cells grow. The 50mg strength is FDA-approved for use in combination with hormone therapy for Stage D2 metastatic prostate cancer, while the 150mg strength has specific restrictions on use.
When you buy Casodex online, you’re getting a proven cancer treatment that requires close supervision by an oncologist or urologist specialist. At Tel Aviv Pharma, Casodex is available with 50mg tablets at $91.00 and 150mg tablets at $219.00 for 28-day supplies. This treatment should only be obtained through licensed providers specializing in cancer medications.
How Casodex Works
Prostate cancer cells typically need testosterone and other male hormones to grow. Bicalutamide blocks androgen receptors in prostate cancer cells, preventing testosterone from attaching and signaling the cells to grow. Think of it like putting a lock on the door – the hormone cant get inside the cancer cell to do its job.
The medication is almost always used in combination with LHRH agonists (like leuprolide or goserelin), which reduce testosterone production in your body. This dual approach – reducing testosterone levels while blocking what remains – provides better cancer control than either treatment alone. The combination therapy helps slow cancer progression, reduce tumor size, and improve survival in men with advanced disease.
Who Should Use This Treatment
Your oncologist may prescribe Casodex if you have Stage D2 metastatic prostate cancer, meaning the cancer has spread beyond the prostate to other parts of your body. This is serious disease requiring specialist care. The treatment is specifically indicated for combination use with LHRH analog therapy, not as a standalone treatment.
The medication is taken as one 50mg tablet daily, either morning or evening, at the same time each day. You can take it with or without food. Treatment with this anti-androgen should start at the same time as your LHRH therapy and continue as long as your oncologist recommends. Never stop taking the medication without consulting your cancer specialist, as this could allow the cancer to grow more rapidly.
Critical Safety Warnings
Liver problems are a serious risk. Severe liver injury and even fatal liver failure have occurred in patients taking this medication, typically within the first 3-4 months. Your doctor will check liver function tests before starting treatment, monthly for the first four months, and periodically after that. Watch for signs like yellowing skin or eyes, dark urine, right-sided stomach pain, nausea, vomiting, or unusual tiredness. If liver enzymes rise too high, the medication must be stopped immediately.
If you take blood thinners (warfarin or other coumarin anticoagulants), this anti-androgen can increase bleeding risk significantly. Some patients have experienced serious internal bleeding requiring hospitalization. Your doctor will monitor blood clotting times closely and adjust medications as needed.
Male-Specific Side Effects of Casodex
Because Casodex blocks male hormones, it causes effects related to reduced testosterone. Breast enlargement (gynecomastia) and breast tenderness occur in many men, affecting up to 38-39% of patients in clinical trials. Hot flashes are very common (occurring in about 53% of men), sexual function changes including reduced libido and impotence are expected, and fertility may be affected. These effects are part of how the medication works, but they can be distressing. Discuss concerns openly with your oncologist – treatment options exist for managing some of these side effects.
Important Specialist Supervision Requirements
This cancer medication requires ongoing care from oncology or urology specialists experienced in treating advanced prostate cancer. Regular monitoring includes PSA (prostate-specific antigen) blood tests to check treatment effectiveness, imaging studies to assess tumor response, liver function tests, and evaluation for disease progression. For comprehensive management of advanced urological cancers, working with experienced cancer specialists ensures proper treatment coordination, side effect management, and optimal outcomes.
| Brand | Casodex Brand |
|---|---|
| Form | 150mg 28 Tablets, 50mg 28 Tablets |
Common Side Effects of Casodex
Very common effects (affecting more than 10% of patients) include hot flashes (53%), general body pain, weakness, constipation, nausea, swelling in extremities, shortness of breath, and anemia. Breast enlargement and tenderness affect up to 38-39% of men. Blood in urine, frequent nighttime urination, and diarrhea are also common.
Serious Side Effects - Seek Emergency Care
Liver failure: Yellowing skin/eyes, dark urine, severe stomach pain, unexplained nausea/vomiting, or extreme fatigue require immediate medical attention. Fatal liver failure has occurred.
Serious bleeding: If you take blood thinners, watch for unusual bruising, bloody or black stools, coughing blood, or severe headaches indicating internal bleeding.
Breathing problems: Severe shortness of breath with or without cough/fever may indicate interstitial lung disease requiring urgent evaluation.
Allergic reactions: Swelling of face/lips/tongue, hives, or difficulty breathing need emergency treatment. Regular monitoring by oncology specialists managing cancer treatment helps catch serious problems early.
FDA-Approved Use
Stage D2 Metastatic Prostate Cancer: Bicalutamide 50mg is FDA-approved specifically for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for treating Stage D2 metastatic carcinoma of the prostate. This represents advanced disease where cancer has spread beyond the prostate to distant sites in the body.
The medication works as an androgen receptor inhibitor, blocking testosterone effects that fuel prostate cancer cell growth. Used together with LHRH analogs (which reduce testosterone production), this dual hormone blockade provides better cancer control than either approach alone.
Important Restrictions
The 150mg daily dose is not approved for use either alone or with other treatments. Clinical trials showed increased mortality risk in certain patient groups with higher doses used as monotherapy.
Treatment Approach
The recommended dose is one 50mg tablet once daily, taken at the same time each day with or without food. Treatment should start simultaneously with your LHRH analog therapy and continue under close oncologist supervision. Regular PSA monitoring and imaging studies assess treatment effectiveness. Complete prescribing information is available in the official FDA product label.
Frequently Asked Questions
Can I take Casodex alone without hormone therapy?
No, the 50mg dose is FDA-approved only for use in combination with LHRH analog hormone therapy (like leuprolide or goserelin). The combination works better than either treatment alone. The 150mg dose is not approved for use alone or with other treatments. Always follow your oncologist's prescribed regimen exactly.
Will Casodex affect my sexual function and fertility?
Yes, because the treatment blocks male hormones, reduced libido and impotence are common. The medication may also impair fertility, though effects might be reversible after stopping. If you have a female partner of childbearing age, use effective birth control during treatment and for 130 days after your last dose, as the medication can cause birth defects.
How long will I need to take this medication?
Treatment typically continues as long as it's controlling your cancer and side effects remain manageable. Your oncologist monitors PSA levels and imaging studies to assess whether the treatment is working. Some men stay on this therapy for years. Never stop without consulting your cancer specialist, as stopping could allow rapid cancer progression. Comprehensive prostate cancer management requires ongoing specialist supervision throughout treatment.
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The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.
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