Lamictal (generic name: lamotrigine) works by stabilizing the electrical activity in the brain, which can help prevent seizures and mood swings.
Antiepileptic
It is prescribed as adjunctive (add-on) therapy for patients two years of age and older suffering partial or primary generalized tonic-clonic seizures, and the severe condition characterized by recurrent seizures in babies known as Lennox-Gastaut syndrome.
Lamotrigine is often used in combination with other antiepileptic drugs to better control seizures including valproic acid, carbamazepine, phenytoin, and topiramate
Lamictal comes in two forms – immediate-release (LTG-IR) and extended-release (LTG-XR). Switching from LTG-IR to LTG-XR can help improve seizure control in some individuals with drug-resistant epilepsy, in addition to improving tolerability.
Antidepressant
Lamotrigine is commonly used to treat Bipolar Disorder type 1. People with bipolar type 1 have episodes of depression and hypomania. Lamotrigine has been found to be effective in reducing symptoms of depression in adolescents and adults with bipolar disorder. It is usually prescribed as an adjunct to drugs such as lithium, which are used to control manic phases of bipolar I disorder.
Unlike some other medications used to treat bipolar disorder, lamotrigine does not typically cause weight gain, which can be the case with other antidepressants in young patients. A specific benefit of using lamotrigine along with lithium to treat bipolar disorder in younger patients is that the drug has been shown to have a protective effect against suicidal behavior. This may be necessary because the other medications have been associated with an increased risk of suicide.
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