Onglyza (saxagliptin) is a prescription diabetes medication that belongs to a class of drugs called DPP-4 inhibitors. This FDA-approved medication helps control blood sugar levels in adults with type 2 diabetes when used alongside diet and exercise. Onglyza works by inhibiting the DPP-4 enzyme, which breaks down incretin hormones like GLP-1. By blocking this enzyme, Onglyza increases insulin secretion when blood sugar is elevated and decreases glucagon production when it’s not needed, providing effective glycemic control throughout the day.

Available as film-coated tablets in two convenient strengths (2.5 mg and 5 mg), Onglyza offers once-daily dosing that fits seamlessly into your diabetes management routine. Unlike some diabetes medications that can cause significant weight gain, Onglyza is weight-neutral, making it an excellent choice for patients concerned about maintaining their current weight.

The active ingredient saxagliptin hydrochloride has been extensively studied in clinical trials, showing consistent efficacy in reducing HbA1c levels when used alone or in combination with other diabetes medications like metformin, insulin, or sulfonylureas. This makes Onglyza a versatile option for various stages of type 2 diabetes management.

Important Storage Information: Store Onglyza tablets at room temperature (68°F to 77°F) in the original container away from moisture and heat. Do not split or crush tablets, as this may affect the medication’s effectiveness.

For patients looking to order Onglyza online, our pharmacy provides genuine AstraZeneca-manufactured medications with secure shipping and pharmacist support. Our streamlined ordering process ensures you can access your diabetes medication quickly and safely.

Brand	Onglyza Brand
Form	2.5mg 30 Tablets, 5mg 30 Tablets

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Common Side Effects

Most patients tolerate Onglyza well, but some may experience mild side effects including:

Upper respiratory tract infections (7.7% of patients)
Urinary tract infections (6.8% of patients)
Headache (6.5% of patients)
Sinusitis and nasal congestion
Abdominal pain and gastroenteritis

Serious Side Effects and Important Safety Information

Pancreatitis Warning: Acute pancreatitis has been reported with Onglyza use. Stop taking Onglyza immediately and contact your healthcare provider if you experience persistent severe abdominal pain that may radiate to your back, with or without vomiting.

Hypersensitivity Reactions: Serious allergic reactions including anaphylaxis, angioedema, and skin reactions have occurred. Symptoms may include swelling of face, lips, throat, difficulty breathing, skin rash, or hives. Discontinue Onglyza and seek immediate medical attention if these symptoms occur.

Hypoglycemia Risk: While Onglyza alone rarely causes low blood sugar, the risk increases when combined with insulin or sulfonylurea medications. Monitor blood glucose levels regularly and be aware of hypoglycemia symptoms.

Joint Pain: Some patients taking DPP-4 inhibitors like Onglyza have reported severe and disabling joint pain. This side effect may occur from one day to years after starting treatment.

Drug Interactions

Onglyza dosage should be limited to 2.5 mg daily when taken with strong CYP3A4/5 inhibitors such as ketoconazole, clarithromycin, or ritonavir. Always inform your healthcare provider about all medications you're taking.

Onglyza is specifically indicated for:

Primary Use

Type 2 Diabetes Mellitus: Onglyza is FDA-approved to improve glycemic control in adults with type 2 diabetes when used as an adjunct to diet and exercise.

Treatment Scenarios

Monotherapy: For patients who cannot achieve adequate control with diet and exercise alone
Combination Therapy: Can be used with metformin, insulin, sulfonylureas, or thiazolidinediones
Add-on Treatment: Ideal for patients requiring additional glucose control beyond their current regimen

Clinical Benefits

Clinical studies demonstrate that Onglyza effectively:

Reduces HbA1c levels by 0.4-0.8% compared to placebo
Improves fasting plasma glucose levels
Provides sustained glucose control over 24 hours
Maintains efficacy when combined with other diabetes medications like Jardiance or Januvia

Important Limitations

Not for Type 1 Diabetes: Onglyza should not be used for type 1 diabetes or diabetic ketoacidosis
Pancreatitis History: Use with caution in patients with a history of pancreatitis
Renal Impairment: Dose adjustment required for moderate to severe kidney problems

Dosage and Administration

What is the recommended starting dose of Onglyza?

The recommended dose is either 2.5 mg or 5 mg once daily, taken with or without food. Your healthcare provider will determine the appropriate dose based on your individual needs and kidney function.

Can I take Onglyza with other diabetes medications?

Yes, Onglyza can be safely combined with metformin, insulin, sulfonylureas, and other diabetes medications. However, combination therapy may increase the risk of hypoglycemia, so blood glucose monitoring is essential.

What should I do if I miss a dose of Onglyza?

Take the missed dose as soon as you remember, unless it's almost time for your next dose. Do not double dose to make up for a missed tablet.

Safety and Side Effects

Is Onglyza safe for patients with kidney problems?

Patients with moderate to severe kidney impairment or end-stage renal disease should take a reduced dose of 2.5 mg once daily. Your healthcare provider will monitor your kidney function regularly.

Can Onglyza cause low blood sugar by itself?

Onglyza alone rarely causes hypoglycemia because it works in a glucose-dependent manner. However, when combined with insulin or sulfonylureas, the risk of low blood sugar increases.

What are the signs of serious allergic reactions to Onglyza?

Serious allergic reactions may include swelling of the face, lips, or throat, difficulty breathing, skin rash, or hives. Stop taking Onglyza immediately and seek emergency medical care if these symptoms occur.

Ordering and Prescription Information

Do I need a prescription to order Onglyza online?

Yes, Onglyza requires a valid prescription from a licensed physician. You can easily order Onglyza online by following our simple 3-step process and submitting your prescription.

How long does it take to receive my Onglyza order?

Most orders are shipped within 1-2 business days and typically arrive within 7 days. For detailed shipping information, please visit our FAQ page or contact us directly.

Can I switch from Januvia or other diabetes medications to Onglyza?

Switching between diabetes medications should only be done under medical supervision. Onglyza offers similar efficacy to other DPP-4 inhibitors like Januvia but may have different side effect profiles that your doctor will consider.

Comparison with Other Medications

How does Onglyza compare to Jardiance or Farxiga?

While Onglyza is a DPP-4 inhibitor, Jardiance and Farxiga are SGLT2 inhibitors with different mechanisms of action. Your healthcare provider can help determine which medication class is most appropriate for your diabetes management needs.

Is Onglyza more effective than metformin alone?

Onglyza and metformin work through different mechanisms and are often used together for enhanced glucose control. Clinical studies show that the combination provides better HbA1c reduction than either medication alone.

For additional questions about Onglyza or to learn more about our ordering process, please visit our comprehensive FAQ section or explore our complete range of diabetes medications.

Brand	Form	Price	Qty	Action
Onglyza Brand	2.5mg 30 Tablets	$99.00	Onglyza quantity
Onglyza Brand	5mg 30 Tablets	$94.00	Onglyza quantity

Onglyza