Prolia, Xgeva
Prolia and Xgeva both contain denosumab, a human monoclonal antibody that prevents bone breakdown by blocking RANK Ligand. While the medications share the same active ingredient, they’re formulated at different doses for distinct therapeutic purposes.
When you buy medications online from Tel Aviv Pharma, you receive authentic denosumab products at prices significantly lower than traditional pharmacies, with convenient worldwide shipping directly to your healthcare provider.
- Prescription Required
| Brand | Form | Price | Qty | Action |
|---|---|---|---|---|
| Prolia Brand | 60mg 1 Vial | $480.00 | ||
| Xgeva Brand | 120mg 1 Vial | $867.00 |
- Please note all prices are in US dollars
What are Prolia and Xgeva?
Prolia and Xgeva are both prescription medications containing the same active ingredient—denosumab, a human monoclonal antibody. While they contain the same drug, they’re used to treat different conditions and at different dosages. Think of them as two specialized tools from the same manufacturer, each designed for specific jobs.
Prolia is specifically designed to treat osteoporosis and prevent bone fractures in adults. Xgeva is used at higher doses to prevent bone complications in cancer patients, particularly those with bone metastases or multiple myeloma.
How Do Prolia and Xgeva Work?
Both medications work by targeting a protein called RANK Ligand, which is responsible for bone breakdown. By blocking this protein, denosumab prevents your bones from being destroyed too quickly. This makes your bones stronger and less likely to break.
Your bones are living tissue that constantly renews itself. In healthy bones, old bone is removed and new bone is formed in a balanced cycle. In osteoporosis or cancer-related bone disease, this balance tips toward too much bone removal. Prolia and Xgeva restore this balance by slowing down bone breakdown while allowing new bone formation to continue.
Pricing
Understanding Prolia cost and Xgeva pricing helps you plan your treatment budget. At Tel Aviv Pharma, we offer competitive pricing.
Prolia 60mg is administered twice yearly to treat osteoporosis and prevent fractures in postmenopausal women, men at risk, and patients experiencing treatment-induced bone loss. The convenient six-month dosing schedule makes it easier to maintain treatment compliance compared to daily or weekly medications.
Xgeva 120mg is given monthly to prevent skeletal complications in cancer patients with bone metastases, multiple myeloma, or giant cell tumors of bone. It significantly reduces the risk of fractures, spinal cord compression, and the need for bone surgery or radiation.
When you buy Prolia online or buy Xgeva online from us, you receive authentic medication with free worldwide shipping. These prices represent significant savings compared to US retail pharmacies, where Prolia can cost over $2,000 per injection.
Prolia: For Osteoporosis and Bone Loss
Prolia 60mg is administered as a single injection under the skin (subcutaneous) once every 6 months. It’s FDA-approved for:
- Postmenopausal women with osteoporosis at high risk for fractures
- Men with osteoporosis at increased fracture risk
- Bone loss in prostate cancer patients receiving hormone therapy
- Bone loss in breast cancer patients taking aromatase inhibitors
- Glucocorticoid-induced osteoporosis (from long-term steroid use)
The twice-yearly dosing makes Prolia convenient compared to daily or weekly osteoporosis medications. You visit your healthcare provider just twice a year for your injections.
Xgeva: For Cancer-Related Bone Complications
Xgeva 120mg is given as a subcutaneous injection once every 4 weeks. It’s approved for:
- Preventing skeletal-related events in patients with bone metastases from solid tumors
- Treating giant cell tumor of bone in adults and skeletally mature adolescents
- Preventing bone complications in multiple myeloma patients
For cancer patients, Xgeva helps prevent fractures, spinal cord compression, and the need for radiation or surgery to bones. This significantly improves quality of life during cancer treatment.
Key Differences Between Prolia and Xgeva
| Feature | Prolia | Xgeva |
|---|---|---|
| Dose | 60mg | 120mg |
| Frequency | Every 6 months | Every 4 weeks |
| Primary Use | Osteoporosis | Cancer bone complications |
| Price | $480 per injection | $867 per injection |
Important Safety Information
Both medications require monitoring and certain precautions. You must take calcium and vitamin D supplements during treatment to prevent low calcium levels. Your doctor will monitor your calcium levels, especially if you have kidney problems.
Good dental hygiene is crucial. Before starting treatment, have a dental check-up and inform your dentist you’re taking Prolia or Xgeva. This helps prevent a rare but serious side effect called osteonecrosis of the jaw.
Prescription Required
Both of these medications require a valid prescription from a licensed healthcare provider. These are administered by healthcare professionals in clinical settings. Our online ordering process makes it easy to submit your prescription and coordinate delivery to your healthcare provider.
| Brand | Prolia Brand, Xgeva Brand |
|---|---|
| Form | 60mg 1 Vial, 120mg 1 Vial |
Very Common Side Effects
More than 1 in 10 patients experience bone, joint, or muscle pain, sometimes severe. Arm or leg pain is also common. These symptoms often improve as your body adjusts to treatment.
Common Side Effects
Affecting up to 1 in 10 patients: back pain, constipation, abdominal discomfort, skin rash, urinary tract infections, upper respiratory infections, sciatica (nerve pain down the leg), and hair loss.
Serious Side Effects - Contact Doctor Immediately
Low calcium levels (hypocalcemia): muscle spasms, twitches, cramps, numbness or tingling in fingers/toes/mouth, seizures, or confusion. This is more common in patients with kidney problems.
Skin infections (cellulitis): swollen, red, hot, tender area of skin (usually lower leg) with possible fever.
Jaw problems (osteonecrosis): jaw pain, swelling, loose teeth, non-healing sores in mouth, or numbness. Rare but more common with long-term use.
Unusual thigh fractures: New or unusual pain in hip, groin, or thigh. Rare but requires immediate attention.
Never stop Prolia suddenly without talking to your doctor, as this significantly increases the risk of multiple spine fractures.
1. Postmenopausal Osteoporosis: Women at high risk for fractures, particularly those who've had previous fractures or have very low bone density.
2. Male Osteoporosis: Men at increased risk for fractures due to aging, low testosterone, or other factors.
3. Androgen Deprivation-Induced Bone Loss: Men with prostate cancer receiving hormone therapy that reduces testosterone levels.
4. Aromatase Inhibitor-Induced Bone Loss: Women with breast cancer taking medications that lower estrogen levels.
5. Glucocorticoid-Induced Osteoporosis: Adults taking equivalent of 7.5mg or more prednisone daily for at least 3 months.
Xgeva is FDA-Approved For:
1. Prevention of Skeletal-Related Events: In patients with bone metastases from solid tumors.
2. Giant Cell Tumor of Bone: In adults and skeletally mature adolescents that cannot be treated with surgery or when surgery would cause severe complications.
3. Multiple Myeloma: Preventing bone damage and fractures.
Age Restrictions
Prolia: Not indicated for use in children or adolescents under 18.
Xgeva: Approved for skeletally mature adolescents with giant cell tumor of bone.
Can Prolia rebuild bone or just prevent loss?
Prolia doesn't just prevent bone loss—it actually increases bone density. Studies show significant increases in spine, hip, and total body bone mineral density. This makes bones stronger and more resistant to fractures over time.
How long does Prolia stay in your system?
Prolia's effects last about 6 months, which is why injections are spaced that far apart. However, the medication itself can remain detectable in your system for up to 9 months after your last injection.
Can I stop taking Prolia if my bone density improves?
No—stopping Prolia suddenly is dangerous. Studies show that discontinuing Prolia can cause rapid bone loss and increased fracture risk, particularly multiple spine fractures. Always discuss any treatment changes with your doctor first.
Do I need calcium and vitamin D supplements?
Yes, absolutely. All patients taking Prolia or Xgeva must take calcium (1000mg daily) and vitamin D (400-800 IU daily) supplements to prevent dangerously low calcium levels. Your doctor will provide specific dosing recommendations.
How is Prolia different from bisphosphonates?
Unlike bisphosphonates like Fosamax, Prolia doesnt accumulate in bones long-term. It's given as injections rather than pills, and it works through a different mechanism (RANK Ligand inhibition vs. osteoclast suppression).
The content on this page has been supplied to telavivpharma.com by an independent third party contracted to provide information for our website. telavivpharma.com relies on these third parties to create and maintain this information and cannot guarantee the accuracy or reliability of the information that has been provided to us.
The drug information provided here is only a summary and does not contain all the list of possible side effects and drug interactions regarding this medication. Be sure to contact your doctor or pharmacist if you have any specific question or concern. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a healthcare professional.
Please note that not all products, including any referenced in this page, are shipped by our affiliated Israel Pharmacy. We are affiliated with other dispensaries that ship product to our customers from the following jurisdictions: Canada, New Zealand, Turkey and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.
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