Climara (estradiol transdermal system) is a once-weekly hormone replacement patch that delivers bioidentical estradiol through the skin to treat menopausal symptoms, hypoestrogenism, and prevent postmenopausal osteoporosis. This convenient patch provides steady hormone levels without daily dosing, making it an effective option for women who prefer transdermal delivery over oral hormone therapy. For patients seeking affordable hormone replacement options, working with qualified healthcare providers ensures proper patch application training, appropriate dose selection, and ongoing monitoring for both therapeutic benefits and potential risks associated with estrogen therapy management.